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Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). With so many options, we often get asked what is the difference between products Yes, Xyzal Allergy 24HR (oral tablets) and Children's Xyzal Allergy 24HR (liquid) are available over-the-counter (OTC) for treatment of symptoms due to seasonal and year-round allergies. Xyzal contains levocetirizine, an antihistamine previously only available by prescription. If you can, consider starting a week or two before you anticipate symptoms will start. Xyzal is one of the newer, third-generation antihistamines used to treat allergies. Xyzal (Levocetirizine) is an allergy medication that is available over the counter beginning Spring 2017. If you experience nasal allergy symptoms year-round, Xyzal also might be a better choice for your symptoms. In a growing trend in the allergy pharmaceutical market, most prescription medications are now becoming over the counter. 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