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One study showed that a small 500 mg dose of valacyclovir is as effective as a larger 800 mg dose of acyclovir in preventing recurrence of HSV eye disease Valacyclovir is superiorto acyclovir in the treatment of herpes zoster. • Valaciclovir is more bioavailable than acyclovir. It can also be used to treat chickenpox in children. Probably the best approach at this point is to promptly (within a couple of days) get professionally examined to confirm the diagnosis of the. Not metabolized by CYP enzymes. Twice-daily valaciclovir proved as effective and well tolerated in the treatment of first-episode genital herpes as five-times-daily acyclovir. "Prepackaged" drug: Valacyclovir is exactly the same as acyclovir, except there is an additional chemical structure stuck to it, that allows the drug to be easily absorbed in the digestive system. Acyclovir may be taken orally in the form of:. 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Prescription only Acyclovir (Zovirax) is an antiviral medication used for the treatment of herpes, shingles, and chickenpox It has a better bioavailability than acyclovir. Valacyclovir may be much more expensive than Acyclovir. Acyclovir and valacyclovir are equally effective. I am so focused on bacteria that I had not considered a viral infectionBut it contains the same active ingredient. Is valacyclovir better than acyclovir? • Side effects are more common in valacyclovir This study compared valacyclovir 1000 mg taken three times a day for seven days with acyclovir 800 mg taken five times a day for seven days. The company that makes valacyclovir (Glaxo) funded the study. On the other hand, acyclovir is available as an oral suspension and tablets that dissolve under the tongue.. 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Acyclovir for cold sores is because of its improved bioavailability, which allows a lower dose of the drug to be used in treatment. Com Valacyclovir (Valtrex) and acyclovir (Zovirax) are antiviral drugs that work by interfering with viral DNA replication. If you are paying out of pocket for these medications, you may discover that there is a steep pricing difference between the two. This results in concentrations in the body that are comparable to those achieved with IV acyclovir. Valacyclovir (Valtrex) and acyclovir (Zovirax) are antiviral drugs that work by interfering with viral DNA replication. Valacyclovir has a longer duration of action than Acyclovir Valacyclovir has a longer duration of action in the body than Acyclovir. Both drugs target the same viruses but valacyclovir provides longer duration of action, therefore, doses can be taken fewer times every day - this is the only real advantage Zovirax (acyclovir) and Valtrex (valacyclovir) are antiviral medications. 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